Miliary Tuberculosis with Addisons Disease - in old case of pulmonary tuberculosis, and tuberculosis of seminal vesicles - A rare case report

Addison's disease is a rare endocrinal disorder that was first described by Thomas Addison in 1855. Addison抯 disease occurs as a result of a lack of production of adrenocortical hormones, which is a rare but fatal disease if left untreated. The two most common causes of Addison's disease are autoimmune adrenalitis and tuberculosis which refer to hypoadrenalism caused by total or near total destruction or dysfunction of both adrenal cortices. Usual manifestations involve chronic fatigue, muscle weakness, loss of appetite, nausea, vomiting, diarrhoea, hypotension, and hyper pigmentation of the skin. A substantial proportion of patients presenting with extra-pulmonary tuberculosis (TB) have urogenital TB (UG-TB), which is easily under diagnosed because of non-specific symptoms, which are chronic and have cryptic protean clinical manifestations. Most of the clinician are not aware of the possibility of UG � TB. Calcification of seminal vesicle found in this case is a rare condition, which is commonly associated with diabetes, hyperparathyroidism, and genitourinary tuberculosis. We here in report a rare case of adrenal insufficiency due to miliary tuberculosis involving adrenal gland, old pulmonary tuberculosis and genitourinary tuberculosis (seminal vesicles calcification) in a 31 year old male person. He presented with multiple episodes of vomiting, and giddiness which wasalso accompanied with atypical hyperpigmentation. His symptoms resolved after starting anti tuberculous therapy.

Diagnostic value of 18F-PSMA-1007 PET/CT in seminal vesicle invasion of prostate cancer / 中华核医学与分子影像杂志

Objective:To evaluate the diagnostic value of the 18F-prostate specific membrane antigen (PSMA)-1007 PET/CT in seminal vesicle invasion (SVI) of prostate cancer. Methods:Clinical and pathological materials of 88 patients (age: 51-84 years) who underwent radical prostatectomy (RP) between May 2019 and December 2021 in the First Affiliated Hospital of Xi′an Jiaotong University were analyzed retrospectively. All patients underwent 18F-PSMA-1007 PET/CT examination for primary staging before surgery. The diagnostic efficiency of 18F-PSMA-1007 PET/CT in SVI was obtained using postoperative pathological results as the " gold standard" and ROC curve was drawn. Furthermore, univariate and multivariate logistic regression analyses were used to screen the influencing factors for 18F-PSMA-1007 PET/CT prediction of SVI. Results:The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of 18F-PSMA-1007 PET/CT in diagnosing SVI were 79.55%(70/88), 72.73%(16/22), 81.82%(54/66), 57.14%(16/28) and 90.00%(54/60), respectively. The ROC AUC was 0.77. Results of univariate logistic regression showed that total prostate specific antigen (tPSA), primary SUV max, Gleason score, International Society of Urological Pathology (ISUP) grade group were associated with 18F-PSMA-1007 PET/CT prediction of SVI. Results of multivariate logistic regression showed that Gleason score (odds ratio ( OR)=2.04, 95% CI: 1.19-3.50, P=0.009) was a predictor of SVI in prostate cancer. Conclusion:18F-PSMA-1007 PET/CT has certain diagnostic value in SVI of prostate cancer, and combining with Gleason score can improve the diagnostic efficiency.

Infertility associated with Zinner syndrome: a case report / 中华泌尿外科杂志

Zinner syndrome is a congenital genitourinary embryo malformation, which is clinically rare, difficult to diagnose, and usually found in the sexually active stage. MRI is the preferred method for diagnosis. Conservative treatment was usually conducted for most asymptomatic patients. Symptomatic patients can be treated by laparoscopic or robotic surgery. For patients with infertility complicated with ejaculatory duct obstruction, transurethral resection of the ejaculatory duct is feasible, which contributes to improving sperm vitality and quantity and increasing semen volume. However, some patients still have azoospermia after surgery. The etiology is needed further studied. A case of infertility with Zinner syndrome and ectopic ureteral opening in seminal vesicle cyst is reported.

Anatomical and histochemical descriptions of the male reproductive system of Diachasmimorpha longicaudata (Ashmed) (Hymenoptera: Braconidae)

ABSTRACT The parasitoid Diachasmimorpha longicaudata is an important control agent for several species of fruit flies. Research on the characteristics of the reproductive system and reproductive biology of this parasitoid can be valuable for studies in taxonomy and phylogeny of insects of the order Hymenoptera. In this study we analyzed the histology and histochemistry of the male reproductive system of D. longicaudata. In this species the male reproductive system consists of a pair of testes, two accessory glands, and an ejaculatory duct. Each testicle consists of only one follicle. The testicular follicles are filled with cysts in different stages of spermatogenesis. Histochemical analyses detected proteins and carbohydrates in the cytoplasm of secretory cells and in the lumen of accessory glands. The morphology of the male reproductive system of D. longicaudata differs in some respects from other species of Hymenoptera.

Mating with seminal vesicle-excised male can affect the uterus phospholipid fatty-acids composition during implantation in an experimental mouse model

ABSTRACT Purpose No comprehensive information is available about uterus fatty acid (FA) change during implantation period and possible effects of the seminal vesicle secretion on it. Materials and Methods In this study, we evaluated FA composition of uterus phospholipids during the implantation period in intact and seminal vesicle-excised (SVX) mated female mice. Forty NMRI female mice were divided into control (mated with intact male) and seminal vesicle excised (SVX)-mated (mated with SVX-male) groups. The phospholipid fatty acids composition was monitored during the first five days of pregnancy using gas chromatography and also implantation rate was evaluated on fifth day of pregnancy. Results We found that levels of linoleic acid (LNA) and arachidonic acid (ARA) showed a decreasing trend from the first to the third day of pregnancy and then started to increase on the fourth day and peaked on the fifth day. In contrast, the level of saturated FA (SFA) increased on the second and third day of pregnancy compared to the first (p<0.05) and then decreased on the fourth and fifth. We also found that the seminal vesicle secretion could affect the levels of LNA, ARA, SFA, and PUFA in uterine phospholipids especially on second and third day. Moreover, there was a positive correlation between ARA level and implantation rate in control but not SVX-mated groups. Conclusions It can be concluded that several uterus FA that have important roles in early pregnancy could be affected by seminal vesicle secretion.

Magnetic resonance imaging and clinical findings in seminal vesicle pathologies

ABSTRACT Purpose Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. Materials and Methods Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI. Congenital and acquired pathology of the SV was identified in 42 of these patients. The patients were categorized according to their SV pathologies. The patients were analyzed in terms of genitourinary system findings associated with SV pathologies. Results SV pathologies were accompanied by other genitourinary system findings. Congenital SV pathologies were bilateral or predominantly in the left SV. Patients with bilateral SV hypoplasia were diagnosed at an earlier age compared to patients with unilateral SV agenesis. There was a significant association between abnormal signal intensity in the SV and benign prostate hypertrophy (BPH) and patient age. Conclusion SV pathologies are rare diseases of the genitourinary system. The association between seminal vesicle pathology and other genitourinary system diseases requires complete genitourinary system evaluation that includes the seminal vesicles.

Resolución laparoscópica de tumores de vesícula seminal: presentación de 2 casos y revisión de la literatura / Laparoscopic resolution of seminal vesicular tumors: 2 cases report and literature review

RESUMEN La patología tumoral de las vesículas seminales es extremadamente poco frecuente. Sólo existen reportes de series de casos que no logran ser más de 150 en todo el mundo. Por lo mismo, no existen pautas de recomendación para el diagnóstico y tratamiento. A propósito de 2 casos de tumores de vesículas seminales ocurridos en un período de 12 meses en nuestro centro, hemos decidido realizar una revisión de la literatura actual sobre el estudio y manejo de esta patología poco frecuente. La sintomatología es inespecífica, y su diagnóstico comprende una combinación de test sanguíneos, imagenológicos e histopatológicos en su mayoría para descartar otras neoplasias. El tratamiento es multimodal el cual incluye resección quirúrgica donde la vía laparoscópica es el patrón de oro, asociado a adyuvancia con hormonoterapia y/o radioterapia. Su pronóstico es pobre debido al diagnóstico en etapas avanzadas, por lo que se requiere un alto índice de sospecha diagnóstica para lograr realizar un tratamiento oportuno.(AU)

Abstract The tumor pathology of the seminal vesicles is extremely rare. There are only reports of series of cases that fail to be more than 150 worldwide. For this reason, there are no recommendation guidelines for diagnosis and treatment. With regard to 2 cases of seminal vesicle tumors that occurred in a period of 12 months in our center, we decided to review the current literature on the study and management of this rare pathology. The symptomatology is non-specific, and its diagnosis includes a combination of blood, imaging and histopathological tests, mostly to rule out other neoplasms. The treatment is multimodal, which includes surgical resection where the laparoscopic approach is the gold standard, associated with adjuvance with hormone therapy and / or radiotherapy. Its prognosis is poor due to the diagnosis in advanced stages, which is why a high index of diagnostic suspicion is required to achieve an opportune treatment.(AU)

Treatment of hemospermia with transprostatic utricle seminal vesiculoscopy / 中国医师进修杂志

Objective To determine the feasibility and safety of transprostatic utricle seminal vesiculoscopy in the treatment of hemospermia. Methods Totally 11 patients with hemospermia, mean age of (46.6 ± 3.5) years, ranging from 38 to 68 years, for 3 months admitted from September 2012 to August 2015 were enrolled, Their main manifestations were hemospermia. Painful ejaculation was observed in 7 patients, and perineal and testicular pain occured in 4 patients. They all underwent transprostatic utricle seminal vesiculoscopy, and then were followed up for 3 to 6 months. Results Ten patients were operated successfully, but 1 patient failed. The operation revealed that the causes of hemospermia were seminal vesiculitis in 8 cases, seminal vesiculitis accompanied with seminal calculi in 2 cases, and ejaculatory duct cyst in 1 case. Operation time was (29.2 ± 3.2) min ( ranging from 25 to 37 min) , and hospital stay was 2 d ( from 2 to 4 d). Hemospermia disappeared in 10 patients within 1 month of surgery, and hemospermia recurrence was observed in 1 patient within 6 months. The patient was treated with transprostatic utricle Holmium laser incision, then hemospermia was dispeared,Two cases of postoperative epididymitis were cured after one week of antibiotic treatment. Conclusions Seminal vesiculoscopy is a safe and effective to treat hemaospermia.

Relation of size of seminal vesicles on ultrasound to premature ejaculation / 亚洲男科学杂志(英文版)

Myriad biological factors have been proposed to explain premature ejaculation (PE). However, data correlating PE with seminal vesicles (SVs) are sparse. The study aimed to evaluate the relationship between the size of SV and PE. The cross-sectional study included 44 outpatients with PE and 44 volunteers without PE, and the size of SV was compared. Self-estimated intravaginal ejaculatory latency time, the Premature Ejaculation Diagnostic Tool (PEDT), the International Index of Erectile Function-15, and the National Institutes of Health-Chronic Prostatitis Symptom Index were used for assessment of symptoms. Compared to the control group, the PE group had significantly higher mean anterior-posterior diameter (APD) of SV (P < 0.001). The optimal mean APD of SV cutoff level was 9.25 mm for PE. In the PE group, PEDT was also higher with a mean APD of SV ≥9.25 mm compared with mean APD of SV <9.25 mm. PEDT was significantly correlated with the mean APD of SV (r = 0.326, P = 0.031). The seminal plasma proteins were compared between six PE and six matched control cases by mass spectrometry and it was shown that 102 proteins were at least 1.5-fold up-or down-regulated. Among them, GGT1, LAMC1, and APP were significantly higher in the PE group. These results indicated that men with a larger mean APD of SV might have a higher PEDT score. Transrectal ultrasound of SV should be considered in the evaluation of patients with premature ejaculation. SV might be a potential target for the treatment of patients with PE and ultrasound change in SV.

Cystic fibrosis transmembrane conductance regulator (CFTR) gene abnormalities in Indian males with congenital bilateral absence of vas deferens & renal anomalies.

Background & objectives: The role of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in congenital bilateral absence of vas deferens and unilateral renal agenesis (CBAVD-URA) has been controversial. Here, we report the cases of five Indian males with CBAVD-URA. The objective was to evaluate the presence or absence of CFTR gene mutations and variants in CBAVD-URA. The female partners of these males were also screened for cystic fibrosis (CF) carrier status. Methods: Direct DNA sequencing of CFTR gene was carried out in five Indian infertile males having CBAVD-URA. Female partners (n=5) and healthy controls (n=32) were also screened. Results: Three potential regulatory CFTR gene variants (c.1540A>G, c.2694T>G and c.4521G>A) were detected along with IVS8-5T mutation in three infertile males with CBAVD-URA. Five novel CFTR gene variants (c.621+91A>G, c.2752+106A>T, c.2751+85_88delTA, c.3120+529InsC and c.4375-69C>T), four potential regulatory CFTR gene variants (M470V, T854T, P1290P, Q1463Q) and seven previously reported CFTR gene variants (c.196+12T>C, c.875+40A>G, c.3041-71G>C, c.3271+42A>T, c.3272-93T>C, c.3500-140A>C and c.3601-65C>A) were detected in infertile men having CBAVD and renal anomalies Interpretation & conclusions: Based on our findings, we speculate that CBAVD-URA may also be attributed to CFTR gene mutations and can be considered as CFTR-related disorder (CFTR-RD). The CFTR gene mutation screening may be offered to CBAVD-URA men and their female partners undergoing ICSI. Further studies need to be done in a large sample to confirm the findings.

Primary Diffuse Large B-Cell Lymphoma of the Seminal Vesicle: a Case Report

Primary diffuse large B-cell lymphoma of the seminal vesicle is an extremely rare disorder, with only two cases reported in the English literature. Here, we present imaging findings of a case of primary diffuse large B-cell lymphoma of the seminal vesicle. On transrectal ultrasonography, the mass presented as a 3.0-cm-sized heterogeneous, hypoechoic lesion in the right seminal vesicle. Computed tomography (CT) revealed a mass with rim-like enhancement in the right seminal vesicle. On magnetic resonance imaging (MRI), the tumor showed iso-signal intensity on T1-weighted images and heterogeneously intermediate-high signal intensity on T2-weighted images. The tumor showed rim-like and progressive enhancement with non-enhancing portion on dynamic scanning. Diffusion restriction was observed in the mass. On fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) imaging, a high standardized uptake value (maxSUV, 23.5) by the tumor was noted exclusively in the right seminal vesicle.

Quiste gigante de vesícula seminal: presentación atípica de una patología infrecuente / Giant seminal vesicle cyst: atypical presentation of a rare disease

Se presenta el caso de un niño de 14 años que hizo una consulta de control por un encondroma en el fémur izquierdo. La resonancia magnética (RM) de caderas reveló, accidentalmente, un quiste gigante de la vesícula seminal derecha. Si bien se indicó una urografía por RM, esta fue suspendida por un cuadro de claustrofobia del paciente y se realizó una tomografía computada abdómino-pélvica con y sin contraste endovenoso. La patología de las vesículas seminales (VS) puede clasificarse en congénita o adquirida. El primer tipo tiene baja prevalencia (siendo el quiste y la agenesia los más comunes en la práctica diaria) y puede coexistir, a menudo, con anomalías ipsilaterales del tracto urinario superior y genital, debido a la estrecha relación en los hombres de los sistemas reproductor y urinario durante la embriogénesis. También se ha descrito su vinculación con anomalías óseas y vasculares. La escasa frecuencia de presentación y el amplio espectro de potenciales hallazgos asociados suelen dificultar el diagnóstico. Lo habitual es iniciar la evaluación con una ecografía abdominal o transrectal, según la edad y tolerancia del paciente, y continuar con una RM, aunque para confirmar los hallazgos pueden ser necesarios otros procedimientos, como la vesículo-deferentografía (VDG). Esta fue tradicionalmente el método de referencia para el diagnóstico, pero en la actualidad se aplica en casos seleccionados. El tratamiento de las malformaciones está restringido a pacientes sintomáticos y usualmente consiste en una vesiculectomía, con o sin extirpación del riñón displásico o hipoplásico

The case is presented of a 14 year-old boy with a previous diagnosis of left femur enchondroma. The pelvic and hip magnetic resonance imaging (MRI) unexpectedly revealed a right giant seminal vesicle cyst. He was evaluated by performing abdominal-pelvic computed tomography, with and without intravenous contrast. The pathology of the seminal vesicles (SV) can be classified as congenital and acquired. The first type has low prevalence (cyst and agenesis being the most frequently encountered in daily practice) and often co-exists with ipsilateral abnormalities in the upper urinary tract and genital organs, due to the close relationship of the male reproductive and urinary systems during embryogenesis. The association with bone and vascular anomalies has also been described. Abdominal and trans-rectal ultrasound, followed by abdominal and pelvic MRI, are the most accurate methods for preoperative diagnosis. Vesiculo-de/erentography (traditionally the gold standard test for diagnosis) is only applied in selected cases. The treatment, vesiculectomy, with or without removal of dysplastic or hypoplastic kidney, is restricted to symptomatic patients

Expression of Vitamin D Receptor in Seminal Vesicles of Cholesterol Formula Mice

OBJECTIVES: Genomic function of vitamin D receptor (VDR) indicates spermatogenesis that is important for in male reproductive organ authors evaluated the VDR expression in seminal vesicles with high cholesterol (HC) formula diet rat, because there is no report about relationship or difference in VDR in seminal vesicles between HC and control. METHODS: Male C57BL/6 mice aged 5 weeks were raised for 13 weeks. After one week of adaptation-period, they were fed different diet on normal AIN-93G diet, or HC diet containing 2% cholesterol for 12 weeks. The antibodies used were rabbit anti-VDR primary polyclonal. RESULTS: There was no significant difference in VDR reactivity in seminal vesicles, body weight of rat and weight of seminal vesicles between HC group and normal control group. CONCLUSION: Our data give the no difference in expression of VDR of seminal vesicles rat between HC formula diet and normal AIN-93G diet. But we confirmed the VDR expression in seminal vesicles.

The Role of Imaging in the Diagnosis of Recurrence of Primary Seminal Vesicle Adenocarcinoma

Primary seminal vesicle (SV) adenocarcinoma is a rare tumor. A small amount of data about the role of imaging to detect tumor recurrence is available. We report the case of a 58-year-old patient with primary SV clear-cell well-differentiated adenocarcinoma. Clinical and instrumental examinations were negative for the 32 months after treatments when computed tomography scan, [18F]fluoro-D-glucose positron emission tomography/computed tomography and pelvic magnetic resonance imaging showed the appearance of a lesion in the left perineal muscle suspected for recurrence. Patient was symptomless. Cytology of the suspected lesion confirmed SV adenocarcinoma recurrence. The combined approach, using radiological and nuclear medicine techniques, seems to be effective in the follow-up of SV adenocarcinoma. Technological advances, together with awareness of this rare tumor, have the potential of improving patients outcomes not only by providing earlier detection and accurate staging, but also by detecting recurrence and thereby avoiding delays and therapeutic dilemmas.

Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review / Paraganglioma da vesícula seminal e carcinoma de células renais cromófobo: um relato de caso e revisão da literatura

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.

CONTEXTO: Paragangliomas extra-adrenais são tumores raros que têm sido relatados em muitas localizações, incluindo rim, uretra, bexiga, próstata, cordão espermático, vesícula biliar, útero e vagina. RELATO DE CASO: Este relato descreve, pela primeira vez em nosso conhecimento, um paraganglioma primário da vesícula seminal ocorrendo em um paciente do sexo masculino de 61 anos de idade. O paciente apresentou hipertensão arterial persistente e um diagnóstico prévio de carcinoma de células renais cromófobo (CCRC). Foi pensado que o tumor de vesícula seminal poderia ser uma metástase do CCRC. A caracterização imunoistoquímica revelou expressão de sinaptofisina e cromogranina nos ninhos de células tumorais e expressão de proteína S100 nas células sustentaculares. Expressão de succinato de-hidrogenase A e B relacionada (SDHA e SDHB) estiveram presentes em ambos os tumores CONCLUSÕES: Nenhuma alteração genética dos genes VHL e SDHB foi detectada nos tecidos tumorais e adjacentes ao tumor, o que nos levou a afastar uma síndrome hereditária que poderia explicar a associação entre o paraganglioma e o CCRC em um paciente com hipertensão arterial.

Seminal Vesicle Involvement by Urothelial Carcinoma in Situ of the Bladder with Mucosal Spread Pattern: A Case Report

Mucosal spreading of urothelial tumors to the seminal vesicles is very rare. We experienced a case of mucosal involvement of the seminal vesicles by a bladder tumor in a 72-year-old man. The patient had a history of transurethral resection for invasive urothelial carcinoma of the bladder 8 years previously. Radical cystoprostatectomy was performed owing to recurrent and multiple urothelial carcinoma in situ. Microscopically, the urothelial carcinoma in situ was throughout the mucosa of the urinary bladder, both ureters, the prostate, and the left seminal vesicle. To date, the implication of mucosal involvement of the seminal vesicles by urothelial carcinoma is unclear. However, careful microscopic examination is needed to avoid an erroneous diagnosis.

Laparoendoscopic Single-Site Surgery (LESS) for Excision of a Seminal Vesicle Cyst Associated with Ipsilateral Renal Agenesis

We report a case of laparoendoscopic single-site surgery (LESS) for a symptomatic left seminal vesicular cyst and ipsilateral renal agenesis. A 49-year-old man presented with a 1-year history of severe irritation upon voiding and intractable, recurrent hematospermia. A computed tomography scan showed a 68x41x38 mm sized left seminal vesicular cyst with ipsilateral renal agenesis. LESS was performed successfully to treat the seminal vesicle cyst. The total operative time was 125 minutes, and blood loss was minimal. The patient was discharged from the hospital on the second postoperative day.

¿Es siempre necesaria la resección de las vesículas seminales durante la prostatectomía radical? / Is seminal vesicle resection always needed during radical prostatectomy?

Introducción: Estudios recientes en pacientes con cáncer de próstata (CP) en estadios precoces han propuesto preservar las VS en la prostatectomía radical (PR) por tener una baja probabilidad de infiltración tumoral, obteniendo una mejor potencia y continencia que en pacientes sometidos a PR “clásica”. El objetivo de esta comunicación fue identificar factores clínico-patológicos preoperatoriosasociados al hallazgo de VS comprometidas en la pieza quirúrgica definitiva. Secundariamente determinarla evolución en el tiempo de este estadio (T3b) y su influencia en la sobrevida libre de enfermedad. Materiales y Métodos: Se revisaron los registros de 632 pacientes con diagnóstico de CP sometidos a PR por enfermedad localizada (T1 - T2) entre 1999 al 2005 en el Hospital Universidad Católica de Chile (HUC) y 1990 al 2005 en el Hospital Sótero del Río (HST). La recidiva bioquímica y sobrevida fue certificada a través de registros clínicos, entrevista telefónica, certificados de defunción y mediciones seriadas de APE. Se definió como recidiva bioquímica a la medición de APE > 0,4 ng/ml. Las variables analizadas en la regresión fueron: la edad y porcentaje de cáncer en la biopsia transrectal como variables continuas y Ape preop (< 10, 10-20,> 20) y puntaje de gleason en la biopsia transrectal (< 7, 7, > 7) como variables categorizadas. Se determinó la sensibilidad (Sen), especificidad (Esp),curvas ROC y área bajo la curva (AUC) para definir el mejor valor de corte que se asociara a compromiso de VS. Resultados: Del total de la serie, 74 pacientes (11,7 percent) presentaron compromiso de VS. El análisis de regresión logística reveló que el porcentaje de cáncer y puntaje de Gleason en la biopsia transrectal fueron factores predictores independientes de compromiso de VS...

Introduction: Recent studies in patients with prostate cancer (PC) in early stages proposed seminalvesicles sparing in radical prostatectomy (RP) due to a low probability of infiltration and better continenceand potency results. The purpose of this communication was to identify preoperative clinical and pathological data associated with seminal vesicles prostate cancer involvement. Secondarily, weassessed the evolution of patients with stage (T3b) disease treated with seminal vesicle sparing(SVS) technique and its influence on disease-free survival. Materials and Methods: Retrospective analysis of data of 632 patients with PC who underwent RP for localized disease (T1 - T2) from 1999 to 2005 at HUC and from 1990 to 2005 at HST. Biochemical recurrence and survival were verified through clinical records, telephone calls and serial PSA measurements. Biochemical recurrence was defined as PSA >0.4 ng / ml. Variables in the regression analysis were: Age and percentage of cancer disease identified in cores from transrectal prostate biopsy were defined as continuous variables. Preop psa (<10 10-20,>20) and Gleason score on biopsy transrectal (<7, 7,> 7) were defined as categorical variables. sensitivity (Sen), specificity (Esp) and ROC curves were calculated to define the best cutting value to be associated with SVS. Results: Seventy four patients (11.7 percent) had received SVS. Logistic regression analysis revealed that the percentage of cancer and Gleason score on transrectal biopsy were independent predictive factors predicting successful surgery treatment with SVS. The best cutoff point using the percentage of cancer in transrectal biopsy was 14.4 percent, with a Sen of 54 percent...

A Patient with Congenital Agenesis of the Seminal Vesicles / 대한남성과학회지

Congenital agenesis of the seminal vesicle is commonly associated with mullerian duct cysts and frequently combined with anomalies of the vas deferens or urinary tract. We report a case of a 29 year-old man with congenital agenesis of the seminal vesicle without any associated anomaly of the urogenital organs. He had infertility for 2 years and two semen analyses revealed azoospermia. There was no abnormal finding in physical examination of the testis, epididymis, or vas deferens. However, we could not locate the seminal vesicles in a transrectal ultrasound and computed tomography. We referred him to an infertility clinic for assisted reproductive technology.

A Patient with Congenital Agenesis of the Seminal Vesicles / 대한남성과학회지

Congenital agenesis of the seminal vesicle is commonly associated with mullerian duct cysts and frequently combined with anomalies of the vas deferens or urinary tract. We report a case of a 29 year-old man with congenital agenesis of the seminal vesicle without any associated anomaly of the urogenital organs. He had infertility for 2 years and two semen analyses revealed azoospermia. There was no abnormal finding in physical examination of the testis, epididymis, or vas deferens. However, we could not locate the seminal vesicles in a transrectal ultrasound and computed tomography. We referred him to an infertility clinic for assisted reproductive technology.